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| S-M | S-LRTs | P | ||
|---|---|---|---|---|
| Major adverse effects of grade 2 or more | ||||
| HFSR | 52 (23.0) | 15 (23.4) | NS | |
| Diarrhea | 37 (16.4) | 10 (15.6) | NS | |
| Skin eruption | 17 (7.5) | 7 (10.9) | NS | |
| Anorexia | 10 (4.4) | 8 (12.5) | 0.034 | |
| Abdominal pain | 19 (8.4) | 8 (12.5) | NS | |
| Sorafenib discontinuation due to adverse effects | 64 (28.3) | 19 (29.7) | NS |
Abbreviations: S-M, sorafenib monotherapy; S-LRTs, sorafenib combined with loco-regional treatments; HFSR, hand foot-skin reaction; NS, not significant.
