Table 1. Clinical characteristics of patients by statin group.
Statin users (n=44) No. (%) | Statin non-users (n=282) No. (%) | p-value | |
---|---|---|---|
Demographics | |||
Male sex | 24 (54.5) | 165 (58.5) | .620 |
Age, median (IQR) years | 64 (56-74) | 57 (43-70) | .006 |
Comorbid conditions | |||
Chronic renal disease | 18 (40.9) | 63 (22.3) | .008 |
Dialysis | 6 (13.6) | 17 (6) | .067 |
Diabetes mellitus | 22 (50) | 67 (23.8) | <.001 |
COPD | 10 (22.7) | 57 (20.2) | .710 |
Chronic heart disease | 25 (56.8) | 61 (21.6) | <.001 |
Cerebrovascular disease | 8 (18.2) | 40 (14.2) | .505 |
Liver disease | 2 (4.5) | 52 (18.4) | .021 |
Malignancy | 16 (36.4) | 111 (39.4) | .692 |
Stem cell transplantation | 2 (4.5) | 20 (7.1) | .394 |
Graft versus Host disease | 0 (0) | 8 (2.8) | .273 |
Solid organ transplantation | 6 (13.6) | 26 (9.2) | .364 |
HIV infection | 0 (0) | 14 (5) | .131 |
Risk factors | |||
ICU stay | 20 (45.5) | 132 (46.8) | .802 |
Mechanical ventilation | 18 (40.9) | 103 (36.5) | .636 |
Total parenteral nutrition | 13 (29.5) | 88 (31.2) | .768 |
Vasopressor therapy | 10 (22.7) | 78 (27.7) | .430 |
Previous surgery | 23 (52.3) | 112 (39.7) | .120 |
Catheter placement (>48h) | 41 (93.2) | 248 (87.9) | .360 |
Urinary catheter | 32 (72.7) | 130 (46.1) | .002 |
Neutropenia | 0 (0) | 42 (14.9) | .006 |
Chemotherapy | 4 (9.1) | 58 (20.6) | .070 |
Radiotherapy | 1 (2.3) | 9 (3.2) | .735 |
Corticosteroid therapy | 15 (34.1) | 133 (47.2) | .122 |
Prior antibiotic therapy | 41 (93.2) | 256 (90.8) | .801 |
Immunosuppressive therapy | 10 (22.7) | 65 (23) | .953 |
Antifungal prophylaxis | 2 (4.5) | 35 (12.4) | .120 |
Clinical characteristics (at candidemia diagnosis) | |||
Fever | 38 (86.4) | 213 (75.5) | .169 |
Hypotension | 26 (59.1) | 125 (44.3) | .293 |
Vasopressor therapy requirement | 16 (36.4) | 83 (29.4) | .402 |
Acute renal failure | 18 (40.9) | 81 (28.7) | .127 |
Confusion | 20 (45.5) | 98 (34.8) | .217 |
APACHE II, median (IQR) | 18 (11-23) | 16 (11-23) | .365 |