Table 1. Demographic, clinical, and genetic features of subjects included in the study.
| HCC | Reference group | |
| n = | 460 | 257 |
| Age years | 66±9 | 48±12 |
| Sex F | 97 (21) | 55 (21) |
| Diabetes | 118 (26) | 0 |
| HCV | 279 (61) | 0 |
| HBV | 65 (14) | 0 |
| Alcohol abuse | 80 (17) | 0 |
| Cirrhosis | 442 (96) | 0 |
| PNPLA3 I148M | ||
| I/I | 194 (42) | 146 (57) |
| I/M | 187 (41) | 95 (37) |
| M/M | 79 (17) | 16 (6) |
(): % values; HCC: hepatocellular carcinoma; HCV: chronic hepatitis C virus infection, HBV: chronic hepatitis B virus infection (co-infected patients were considered in both categories), F: female, PNPLA3: patatin-like phosholipase domain-containing 3. p = 1.8×10−6 for the frequency distribution of the I148M polymorphism between HCC patients and controls.