Figure 4. Systematic search for new predictors associated with clinical variables.

Predictors were built using the tool Prophet and the 54,675 probes contained in the microarray, using the leave-one-out cross-validation strategy, to identify classifiers genes for glucocorticoid sensitivity (A), glucocorticoid dependency (B) or need for surgery (C). Data are represented as box and whiskers plots, where the error bars designate the smallest and largest observations and dots designate the outliers. Data was analyzed by two-way ANOVA followed by Bonferroni post test, p values higher than 0.05 were considered not significant (ns), *p<0.01, **p<0.001.