Skip to main content
. 2013 Oct 14;8(10):e76183. doi: 10.1371/journal.pone.0076183

Figure 2. Effect of in vivo treatment of C-ANP4–23 on DNA synthesis in VSMC from 8 week-old SHR and age-matched WKY rats.

Figure 2

One week old SHR and age matched WKY rats (control) were injected intraperitoneally with C-ANP4–23 (10 nmol/Kg of body weight) twice weekly up to 8 weeks as described in “Methods”. After eight weeks of treatment, the rats were sacrificed and aortic VSMC from SHR and age-matched WKY (control groups) and C-ANP-4–23-treated groups were cultured and thymidine incorporation was determined as described in “Methods”. Results are expressed as % of WKY CTL, taken as 100%. Values are means ± SE of 3 separate experiments.. *** P<0.001 vs WKY, ### P<0.001 vs SHR.