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. 2013 Oct 14;8(10):e76169. doi: 10.1371/journal.pone.0076169

Figure 3. Anti-proliferative effect of docetaxel (D), gefitinib (G), and NS-398 (N) in PC-3M and DU-145 cell lines evaluated by the MTT assay.

Figure 3

The concentration-response response for each drug was used to determine the concentration that induced an appropriate anti-proliferative effect for use in combination therapy (data not shown). Cells were exposed to docetaxel (0.01 μmol/L), NS-398 (100 μmol/L) and gefitinib (20 μmol/L) alone or in combination for 24 h. Values are means±SD of four independent experiments. *P <0.05, ** P <0.005 ***, P <0.001 as compared with control values.