Table 1. Electrophysiological phenotypes of L1CAM-constructs in nrg14;P[nrg180ΔFIGQY] background.
Genotype | n | FF in % | NR in% | RL in ms |
OK307,UAS-L1 | 16 | 99.75±0.17 | 0 | 0.87±0.02 |
OK307,UAS-L1-L1180 | 16 | 99.3±0.63 | 0 | 0.9±0.02 |
OK307,UAS-L1-4A | 20 | 99.5±0.05 | 0 | 0.84±0.01 |
OK307,UAS-L1-L120V | 20 | 99.5±4.5 | 0 | 0.78±0.04 |
OK307,UAS-L1-E309K | 12 | 99.5±0.26 | 0 | 0.9±0.16 |
OK307,UAS-L1-C264Y | 25 | 100±0 | 0 | 0.9±0.03 |
OK307,UAS-L1-Y1070C | 20 | 99.2±2.46 | 0 | 0.9±0.002 |
OK307,UAS-L1-H210Q | 22 | 99.2±1.89 | 0 | 1.02±0.03 |
OK307,UAS-L1-R184Q | 18 | 99.6±0.33 | 0 | 0.8±0.02 |
nrg14/>;P[nrg180ΔFIGQY] | 24 | 4.04±1.10 | 37 | 2.05±0.13 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1 | 10 | 98.5±1.5 | 0 | 0.87±0.02 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-1180 | 12 | 2±1.12 | 83 | 2.24±0.12 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-4A | 18 | 90±3.33 | 0 | 0.91±0.01 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-L120V | 24 | 92±3.42 | 0 | 0.98±0.02 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-E309K | 21 | 89±4.62 | 0 | 0.98±0.07 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-C264Y | 25 | 52±8.59 | 8 | 1.36±0.11 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-Y1070C | 20 | 17±6.55 | 25 | 1.64±0.13 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-H210Q | 17 | 4±17 | 76 | 2.21±0.21 |
nrg14/>;P[nrg180ΔFIGQY]/OK307,UAS-L1-R184Q | 22 | 3.5±1.08 | 23 | 2.10±0.13 |
Intracellular recordings from the TTM upon GF stimulation in the brain. The average Following Frequency (FF), and Response Latency (RL) shown with standard error of the mean. The TTM recordings that showed no responses (NR) upon GF stimulation in brain are shown in %. Non-responders were not included in the calculation of the average Response Latency.