Table 3. Haplotype frequencies of four polymorphisms examined in RAGE gene between patients and controls and their risk prediction for coronary artery disease.
| Haplotype* | CAD patients | Controls | PSim | OR; 95% CI; P† |
| T-T-G-G | 25.68 | 26.36 | 0.1026 | Reference group |
| T-T-A-G | 16.44 | 17.94 | 0.1225 | 0.97; 0.76–1.21; 0.6274 |
| C-T-G-G | 13.95 | 9.92 | 0.0038 | 1.52; 1.19–1.87; 0.0052 |
| T-A-G-G | 9.08 | 11.9 | 0.009 | 0.79; 0.52–1.06; 0.1115 |
| C-T-A-G | 7.72 | 6.17 | 0.0387 | 1.33; 0.91–1.82; 0.1397 |
| T-T-G-T | 6.64 | 4.41 | 0.0184 | 1.53; 0.97–2.11; 0.0806 |
| T-A-G-T | 5.75 | 3.1 | 0.0091 | 1.63; 1.14–2.34; 0.0075 |
| T-A-A-G | 4.75 | 5.48 | 0.2145 | 0.98; 0.66–1.46; 0.8347 |
| C-A-G-G | 2.88 | 3.55 | 0.2798 | 0.91; 0.53–1.37; 0.7904 |
Abbreviations: CAD, coronary artery disease, PSim, simulated P value; OR, odds ratio; 95% CI, 95% confidence interval. PSim was calculated based on randomly permuting the trait and covariates and then computing the haplotype score statistics. *Alleles in haplotype were presented in order of polymorphisms rs1800625, rs1800624, rs2070600 and rs184003. †OR, 95% CI, and P values were calculated after considering age, gender, body mass index, systolic blood pressure, and fasting glucose as covariates.