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Yohimbine has no effect on cue fear extinction when injected immediately after massed CS presentations. Separate experiments examined the effect of injecting vehicle, yohimbine, or propranolol after 10 (A) or 20 (B) massed CS presentations (eight mice/group). The data shown represent freezing during a single 2-min CS given 1 d after the extinction sessions (drug free). Retention control (RC) mice received no CS presentations and were injected with vehicle on Day 2.
