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. 2013 Oct 11;54(10):6675–6685. doi: 10.1167/iovs.13-12550

Figure 2.

Figure 2

In the absence of kl, synaptic proteins are altered by 7 weeks of age. All IHC representative images are from 7-week-old wild-type or knockout mouse retina. White bars denote wild-type and grey bars denote knockout quantification. (A) Representative synaptophysin IHC images and quantification. Quantification of synaptophysin signal in IPL and OPL was conducted across multiple retinas at 3 weeks (striped bars) and 7 weeks (solid bars) (n = 4–5 per group, ±SEM, significance determined by Student's t-test: *P < 0.01, **P < 0.005). (B) Representative PSD95 IHC images and quantification. Quantification detected no significant differences at 7 weeks (n = 5 per group, ±SEM). (C) Representative calbindin IHC images and quantification. Quantification of calbindin positive cell number was conducted across multiple retinas at 7 weeks (n = 6 per group, ±SEM). (D) Representative GAD67 IHC images and quantification. Quantification of GAD67 signal in IPL was conducted across multiple retinas at 3 weeks (striped bars) and 7 weeks (solid bars) (n = 5 per group, ±SEM, significance determined by Student's t-test: *P < 0.02).