Table 2.
Prevalence of CD detected by screening in patients presenting with low bone mineral density
| AUTHOR, YEAR, COUNTRY | T-SCORE | SAMPLE SIZE | FEMALE SEX, % | AGE, Y | SCREENING ALGORITHM | BIOPSY CRITERIA | CD PREVALENCE (95% CI), % |
|---|---|---|---|---|---|---|---|
| Drummond et al,52 2003, Ireland | ≤ −1.0 | 366 | 100 | Mean 56 (SD 11.5; range 28–96) | IgA EMA and IgA tTG | NA | 2.2 (1.1–4.2) |
| González et al,53 2002, Argentina | < −2.5 | 127 | 100 | Mean 68 (range 50–82) | 1. IgA AGA 2. IgA EMA |
Marsh III | 0.8 (0.02–4.31) |
| Lindh et al,54 1992, Sweden | NA | 92 | 91 | Mean 66 (SD 12) | IgA AGA | NA | 3.3 (1.1–9.1) |
| Mather et al,55 2001, Canada | ≤ −1.0 | 96 | 81 | Mean 57 (range 18–86) | IgA EMA | NA | 0 (0–3.8) |
| Nuti et al,56 2001, Italy | ≤ −2.5 | 255 | 100 | Mean 66 (SD 8.5) | 1. IgA AGA 2. IgA tTG |
NA | 2.3 (1.1–5.0) |
| Sanders et al,57 2005, United Kingdom | ≤ −1.0 | 674 | 95 | Mean 53 (range 21–69) | IgA AGA and IgA EMA | ESPGHAN | 1.5 (0.8–2.7) |
| Stenson et al,58 2005, United States | ≤ −2.5 | 266 | 90 | Mean 57 (SD 12) | IgA EMA and IgA tTG | Marsh III | 3.4 (1.8–6.3) |
| Karakan et al,59 2007, Turkey | ≤ −1.0 | 135 | 90 | Mean 57.2 (range 24–81) | IgA EMA | NA | 0 (0–2.7) |
AGA—antigliadin antibody, CD—celiac disease, EMA—endomysial antibody, ESPGHAN—European Society of Paediatric Gastroenterology, Hepatology and Nutrition, Ig—immunoglobulin, NA—not available, tTG—tissue transglutaminase.