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. 2013 Oct 15;8(10):e76342. doi: 10.1371/journal.pone.0076342

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© 2013 Miller et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Blood-filled blisters are evident in the hindlimbs of Fras1^bfb/bfb at E14.5 (A and B) and E17.5 (C and D), often distorting the digits. A proportion of Fras1^bfb/bfb exhibit preaxial polydactyly (asterisks in E-H), evident in E14.5 and E17.5 wholemounts (E and F), E17.5 skeletal preparations (G) and E12.5 Sox9 in situ stained embryos (H). Evidence of a blister can also be seen in an E17.5 skeletal preparation (arrowhead in G). Digit numbers are indicated in (G).