Table 1. Phenotypes observed in Fras1bfb/bfb embryos.
Age | Ex | Head | Eyelid | Eye (R) | Eye (L) | FL | HL (R) | HL (L) | Pd | Ster | GCP | PB | Kid | Ph |
≤E11.5 | - | 2/17 (12%) | - | - | - | - | - | - | 1/17 (5%) | - | - | - | - | 2/17 (12%) |
≥E12.5 | 10/12 1 (8%) | 17/121 (14%) | - | 18/121 (15%) | 25/121 (21%) | 0/121 (0%) | 30/121 (25%) | 53/121 (44%) | 16/121 (13%) | - | - | - | 21/23 (91%)? | 96/121 (80%) |
>E15.5 | - | - | 28/38 (74%) | - | - | - | - | - | - | 9/10 (90%)# | 7/42 (17%) | 19/23 (83%)* | - | - |
Ex; exencephaly, FL; forelimbs, HL; hindlimbs, Pd; Polydactyly, Ster; sternum, GCP; gross cleft palate, PB; palate blister, Kid; no kidneys, Ph; any observed phenotype, R; right, L; left. #≥E17.5, *Age E15.5 only, no palate blisters identified at E17.5 (4/4), ?includes 5/23 small/abnormal or only 1 kidney.