Table 3.

Adjusted means of the metabolite indices after simultaneously controlling for sex, age, body mass index, and creatinine

Metabolite	ASD			Control			F	(1,df)	p	d
	N	M	SD	N	M	SD
Total MEHP	50	20.18	24.63	53	15.80	24.60	.47	97	.50	0.14
Total 5-OH-MEHP	50	10.84	12.94	52	10.66	12.93	3.58	96	.06	0.39
Total 5-oxo-MEHP	50	5.31	5.94	53	5.00	5.93	1.88	97	.17	0.28
Total 5-cx-MEPP	48	433.89	436.57	51	341.06	436.04	.38	93	.54	0.13
Total Metabolites	48	464.86	469.42	50	380.58	469.02	.43	92	.51	0.14
Free MEHP	50	7.42	1.15	53	6.79	1.14	7.62	97	.01*	0.56
Free 5-OH-MEHP	50	.72	1.13	52	.56	1.13	.29	96	.59	0.11
Free 5-oxo-MEHP	50	.32	.40	53	.18	.39	5.04	97	.03*	0.46
Free 5-cx-MEPP	48	309.68	316.09	51	247.63	315.71	.24	93	.63	0.10
Total free metabolites	48	314.13	317.55	50	260.18	317.27	.06	92	.80	0.05
% Bound MEHP	50	37.76	19.84	53	48.11	19.82	6.73	97	.01**	0.53
% Bound 5-OH-MEHP	50	90.80	12.03	52	95.11	12.01	.30	96	.59	0.11
% Bound 5-oxo-MEHP	50	90.22	11.80	53	96.49	11.79	4.88	97	.03*	0.45
% Bound 5-cx-MEPP	48	24.98	20.68	51	30.92	20.65	1.96	93	.16	0.29

With the exceptions of the % Bound MEHP and % Bound 5-cx-MEPP indices which were normally distributed, all of the multiple regression analyses are based on log10 transformations of the metabolite values. The % Bound 5-OH-MEHP and % Bound 5-oxo-MEHP were negatively skewed and the log10 transformation applied to them was based on first subtracting the values for these latter two % Bound indices from 100 and adding .05. The F and d statistics are based on the log10 transformed data as noted above where appropriate and apply to adjusted mean differences, but the adjusted Ms and SDs for the log10 transformed metabolite data have been converted back to their untransformed metabolite values to facilitate interpretation

MEHP monoethylhexylphthalate, 5-OH MEHP 5-hydroxy-methylethylhexyl phthalate, 5-oxo MEHP 5-oxo-methylethylhexyl phthalate, 5-CX MEPP 5-carboxy-methylethylhexyl phthalate, d effect size

^*p < .05,

^**p<.01 two-tailed tests