Table 2.
Pooled ORs (95% CI) for association Between LGA and risk of Acute Lymphocytic Leukemia among 12 studies: Overall and by Subgroup, Childhood Leukemia International Consortium
| Total N1 Cases/Controls | Cases n LGA/AGA | Controls n LGA/AGA | OR2 | 95% CI | |
|---|---|---|---|---|---|
| Overall | 7,292/12,406 | 988/5,670 | 1,398/9,779 | 1.21 | 1.11, 1.32 |
| Excluding studies if <80% participants had LGA data3 | 6,542/11,294 | 874/5,088 | 1,247/8,933 | 1.22 | 1.11, 1.34 |
| Excluding studies with hospital controls4 | 6,311/11,386 | 823/4,929 | 1,243/9,017 | 1.23 | 1.12, 1.36 |
| Excluding studies with <300 cases5 | 7,000/11,902 | 939/5,443 | 1,327/9,393 | 1.22 | 1.11, 1.34 |
| Birth weight <4,000g | 6,394/11,077 | 297/5,463 | 408/9,440 | 1.26 | 1.07, 1.48 |
| Sex6 | |||||
| Males | 4,106/6,905 | 552/3,192 | 782/5,435 | 1.18 | 1.05, 1.33 |
| Females | 3,186/5,501 | 436/2,478 | 616/4,344 | 1.25 | 1.09, 1.43 |
| Age at diagnosis7 | |||||
| 0-1 | 636/1,447 | 76/521 | 154/1,149 | 1.04 | 0.75, 1.44 |
| >1-5 | 4,075/6,087 | 559/3,178 | 712/4,808 | 1.20 | 1.06, 1.35 |
| >5 | 2,581/4,872 | 353/1,971 | 532/3,822 | 1.26 | 1.08, 1.46 |
| Ethnicity8 | |||||
| White/European/Caucasian | 6,042/10,858 | 812/4,747 | 1,232/8,618 | 1.18 | 1.07, 1.30 |
| Other | 1,250/1548 | 176/923 | 166/1,161 | 1.44 | 1.14, 1.83 |
| Immunophenotype | |||||
| B-lineage cases | 5,735/12,406 | 771/4,456 | 1,398/9,779 | 1.20 | 1.09, 1.33 |
| T-lineage cases | 705/12,406 | 105/546 | 1,398/9,779 | 1.32 | 1.05, 1.64 |
1
Total N includes those born SGA. Counts for cases and controls by LGA/AGA represent exposure of interest and reference group only.
2
ORs adjusted for child’s age group, sex, year of birth group, mother’s age group, parental education, ethnic Group, birth order group and study.
3
Greece, Australia
4
Greece, Brazil, France (Adele)
5
France (Adele), New Zealand
6
P-value of sex by LGA interaction term = 0.50
7
P-value of age by LGA interaction term = 0.66
8
P-value of ethnic group by LGA interaction term = 0.25