Table 4.
Pooled ORs (95% CI) for Association Between POBW and Risk of Acute Lymphocytic Leukemia among 3 Studies1: Overall and by Subgroup, Childhood Leukemia International Consortium
| Subgroup | N Cases/controls | Pooled OR2 | 95% CI |
|---|---|---|---|
| Overall | 1,689/3,154 | 1.16 | 1.09, 1.24 |
| Excluding Australia | 1,345/2,394 | 1.16 | 1.08, 1.24 |
| Excluding UK | 816/1,502 | 1.16 | 1.07, 1.27 |
| Excluding USA (NCCLS) | 1,217/2,412 | 1.17 | 1.09, 1.26 |
| Birth weight <4,000g | 1,467/2,771 | 1.21 | 1.12, 1.31 |
| Sex of child3 | |||
| Males | 954/1,746 | 1.11 | 1.02, 1.21 |
| Females | 735/1,408 | 1.22 | 1.12, 1.34 |
| Age at diagnosis (years) 4 | |||
| 0-1 | 179/268 | 1.09 | 0.87, 1.37 |
| >1-5 | 971/1,769 | 1.17 | 1.08, 1.27 |
| >5 | 539/1,117 | 1.18 | 1.06, 1.31 |
| Ethnic Group5 | |||
| White/European/Caucasian | 1,281/2,583 | 1.14 | 1.06, 1.23 |
| Other | 408/571 | 1.22 | 1.08, 1.39 |
| Immunophenotype | |||
| B-lineage cases | 1,400/3,154 | 1.17 | 1.09, 1.24 |
| T-lineage cases | 161/3,154 | 1.22 | 1.04, 1.43 |
1
Australia, USA (NCCLS), and UK
2
ORs adjusted for child’s age group, sex, year of birth group, mother’s age group, parental education, ethnic group and study.
3
P-value of sex by POBW interaction term = 0.14
4
P-value of age by POBW interaction term = 0.90
5
P-value of ethnic group by POBW interaction term =0.39