Table 3.

Plasma cotinine levels in lesioned wild type and knockout mice treated with nicotine. Unilateral 6-OHDA-lesioned L-dopa-treated wild type and null mutant mice were given saccharin without and with nicotine (300 µg/ml) in the drinking water. Plasma cotinine levels shown were measured 2 to 3 months after the start of nicotine treatment, and are representative of the levels throughout the study. Cotinine levels were not detected in saccharin-treated mice. Values represent the mean ± SEM of 10–17 mice.

nAChR subunit deletion	Group	Cotinine level (ng/ml)
α4	Wild type Null mutant	384 ± 110 350 ± 71
α7	Wild type Null mutant	280 ± 71 301 ± 77