Table 4.
Summary of all chromosomal regions with multipoint LOD scores reaching suggestive evidence for linkage.
| Dimension | Chr | Location (cM / Mb) | Peak LOD | 1-LOD Interval (cM / Mb) | Nearest Genes | Nearby Genes of Interest |
|---|---|---|---|---|---|---|
| NS | 7q21 | 104 / 92.7 | 2.25 | 101-115 / 89.6-105.2 | CCDC132 | RELN |
| 10p15 | 5 / 2.3 | 3.40 | 1-16 / 0.1-5.1 | ADARB2 | ||
|
| ||||||
| PS | 6q16 | 107 / 103.7 | 2.27 | 101-114 / 95.2-110.0 | GRIK2 | POU3F2 |
| 12p13 | 0 / 0.2 | 2.20 | 0-11 / 0.2-3.9 | CACNA1C | ||
| 19p13 | 42 / 17.6 | 2.44 | 39-46 / 16.0-19.3 | UNC13A | HOMER3, NCAN | |
|
| ||||||
| SD | 4q35 | 183 / 183.3 | 2.27 | 181-192 / 182.7-186.1 | ODZ3 | CASP3 |
| 8q24 | 122 / 122.1 | 2.70 | 120-126 / 120.2-124.1 | SNTB1 | ||
| 18q12 | 56 / 29.9 | 3.53 | 55-61 / 28.4-36.7 | NOL4 | ||
Key: 1-LOD interval = genetic and physical boundaries of LOD scores within one unit of the maximum; Nearest genes = genes immediately flanking the peak LOD score, with those of particular interest based on function or previous studies underlined; Nearby Genes of Interest = genes within the 1-LOD interval that are expressed in brain or have been implicated in previous studies of psychiatric illness.