Table 5.
Progression-free survival (PFS) according to different variables in univariate and multivariate analyses
| Variable | Group | n | Median PFS in months (95% CI) |
P-value
|
|
|---|---|---|---|---|---|
| Univariate | Multivariate | ||||
| Age (years) | <50 | 34 | 9.8 (7.3–12.2) | 0.42 | NA |
| ≥50 | 26 | 11.8 (9.6–14) | |||
| Sex | Female | 26 | 9.7 (5.5–13.9) | 0.026 | 0.006 |
| Male | 34 | 12 (6.7–17.3) | |||
| Presurgery volume (cc) | <30 | 24 | 11.8 (8.8–14.9) | 0.067 | 0.1 |
| 30 to <50 | 22 | 9.8 (6.8–12.7) | |||
| ≥50 | 14 | 7.6 (1.7–13.5) | |||
| Surgery extent | Near total | 14 | 9.7 (4.3–15.2) | 0.249 | NA |
| Subtotal | 24 | 10.6 (6.4–14.9) | |||
| Biopsy | 22 | 11.8 (9.1–14.6) | |||
| Postsurgery residual volume (cc) | ≤10 | 18 | 13.5 (10.9–16.1) | 0.043 | 0.016 |
| >10 | 42 | 8.8 (7–10.7) | |||
| KPS | ≤80 | 46 | 9.7 (6.6–12.9) | 0.09 | 0.02 |
| >80 | 14 | 13.5 (9.2–17.8) | |||
| Posttreatment (radio/chemotherapy) volume | ≤10 | 26 | 13.4 (8.8–18.1) | 0.056 | 0.054 |
| >10 | 34 | 8.7 (6.6–10.9) | |||
| Treatment arm | I | 30 | 8.8 (5.9–11.7) | 0.571 | NA |
| II | 30 | 11.5 (8.9–14.2) | |||
| Response to treatment | Yes | 20 | 10.6 (8.5–12.8) | 0.98 | NA |
| No | 40 | 9.8 (5.8–13.7) | |||
Abbreviations: CI, confidence interval; NA, not applicable (multivariate [Cox regression] analysis included variables with a P-value ≤0.2 in univariate analysis); KPS, Karnofsky Performance Status.