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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2013 Aug 8;4(6):723–735. doi: 10.1002/wrna.1191

Figure 1. Flavivirus Genomic RNA Structures.

Figure 1

A) Linear structure of a generic flavivirus RNA genome showing the positions of critical RNA structures and protein coding regions. B) Cyclization of Flavivirus positive strand genome promotes negative strand RNA synthesis. The 5′ end of the positive strand genomic RNA interacts with the 3′ end of the positive strand RNA via interactions between the CS and UAR/DAR regions. Hybridization between the 5′ UAR and 3′ DAR causes a re-organization of the 3′ SL structure, exposing the 3′ end of the positive strand RNA. The RdRP domain of NS5 binds to SLA on the 5′ end of the positive strand genome and utilizes the exposed 3′ end of the positive strand RNA as a template for negative strand RNA synthesis.