Table 1. Characteristics of prostate cancer cases at the time of prostatectomy, Health Professionals Follow-up Study.
| All Men† | Telomere length among prostate cancer cells and telomere length in prostate cancer-associated strom cells ‡ | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Less variable/longer | More variable/longer | Less variable/longer | More variable/longer | P1 | ||
| Number of men | 596 | 98 | 91 | 280 | 98 | |
| Mean ± standard deviation age at diagnosis (years) | 65.3 ±6.1 | 65.7 ± 6.4 | 65.6 ± 6.2 | 65.0 ± 6.0 | 65.9 ± 6.2 | 0.51 |
| White (%) | 91.1 | 87.8 | 89.0 | 93.9 | 87.8 | 0.12 |
| Mean ± standard deviation year of diagnosis (years) | 1994.2 ± 3.2 | 1994.7 ± 3.3 | 1994.6 ± 3.4 | 1993.8 ± 3.1 | 1994.5 ± 3.1 | 0.04 |
| Prostatectomy Gleason sum (%) | ||||||
| ≤6 | 21.3 | 21.4 | 11.0 | 23.9 | 13.3 | |
| 3+4 | 35.8 | 42.9 | 35.1 | 35.7 | 30.6 | |
| 4+3 | 24.8 | 23.5 | 29.7 | 25.4 | 26.5 | 0.006 |
| ≥8 | 18.1 | 12.2 | 24.2 | 15.0 | 29.6 | |
| Pathologic stage ≥T3b (%) | 12.6 | 5.1 | 18.7 | 12.1 | 17.3 | 0.02 |
| Serum PSA concentration at diagnosis in ng/mL (%) | ||||||
| <10 | 59.2 | 73.5 | 54.9 | 57.5 | 54.1 | |
| 10-20 | 17.6 | 14.3 | 17.6 | 17.5 | 20.4 | |
| >20 | 10.1 | 4.1 | 14.3 | 10.7 | 11.2 | 0.17 |
| Unknown | 13.1 | 8.1 | 13.2 | 14.3 | 14.3 | |
1
From a chi-square test for proportions and a one-way ANOVA for means
†
Among all men
‡
Among men for whom telomere length could be determined for both prostate cancer cells and prostate cancer-associated stromal cells (N=567)