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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: J Comp Neurol. 2013 Dec 15;521(18):10.1002/cne.23411. doi: 10.1002/cne.23411

Figure 5.

Figure 5

Accumulation of amyloid plaques in APP/PS1 × rTgTauEC mice does not accelerate the spread of tau pathology into granule cells of the dentate gyrus. Horizontal sections (10 μm) of either rTgTauEC (A, B) or APP/PS1 × rTgTauEC (C, D) mouse dentate gyrus were immunostained with an antibody against human tau (Tau13: B, D) and co-stained with DAPI to label cell nuclei (A, C). APP/PS1 × rTgTauEC mice displayed tau-positive (Tau13) neurons in the granule cell layer, similar to the neurons observed in the mice expressing rTgTauEC only. Scale bar = 50 μm.