Table IV.
FIC indices from interaction studies between polycationic peptides and clinically used antibiotics (continued).
| Agent | P. aeruginosa ATCC 27853 | P. aeruginosa 8–97 | P. aeruginosa 17–99 | E. coli ATCC 25922 | E. coli 31–97 | E. coli 7–98 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| MG II | RNL | MG II | RNL | MG II | RNL | MG II | RNL | MG II | RNL | MG II | RNL | |
| AMC | 0.187 | 1.000 | 0.187 | 1.000 | 0.187 | 0.750 | 0.187 | 1.500 | 0.312 | 1.250 | 0.187 | 1.000 |
| PIP | 0.250 | 0.750 | 0.187 | 1.000 | 0.250 | 1.000 | 0.312 | 0.750 | 0.312 | 1.250 | 0.250 | 1.000 |
| CAZ | 0.250 | 1.250 | 0.375 | 1.500 | 0.250 | 1.000 | 0.187 | 1.250 | 0.187 | 1.250 | 0.312 | 1.250 |
| CRO | 0.250 | 1.000 | 0.312 | 0.750 | 0.250 | 1.250 | 0.250 | 1.000 | 0.312 | 1.250 | 0.250 | 1.250 |
| MEM | 0.187 | 0.750 | 0.250 | 1.000 | 0.312 | 0.750 | 0.312 | 0.750 | 0.375 | 1.000 | 0.375 | 1.500 |
| CLR | 1.000 | 0.250 | 1.500 | 0.375 | 1.500 | 0.250 | 1.500 | 0.375 | 1.500 | 0.312 | 1.500 | 0.312 |
| D | 1.500 | 0.250 | 1.500 | 0.312 | 2.000 | 0.375 | 1.500 | 0.312 | 1.250 | 0.375 | 2.000 | 0.312 |
| POL-E | 1.250 | 0.250 | 1.250 | 0.250 | 1.000 | 0.250 | 1.500 | 0.187 | 1.500 | 0.250 | 1.250 | 0.312 |
FIC, fractionary inhibitory concentration; P. aeruginosa, Pseudomonas aeruginosa; E. coli, Escherichia coli; MG II, magainin II; RNL, ranalexin; AMC, amoxicillin-clavulanate; PIP, piperacillin; CAZ, ceftazidime; CRO, ceftriaxone; MEM, meropenem; CLR, clarithromycin; D, doxycycline; POL-E, polymyxin E.