Figure 2.

A, B, Whole-cell patch recording demonstrates the modulation of outward currents by endogenous SLOB in motor neurons in vivo. Using voltage-clamp mode, large outward currents were evoked by 150 ms depolarizing voltage steps from a holding potential of −70 mV to potentials ranging from −60 to +50 mV in 10 mV increments, in motor neurons from wild-type (A) and slob null (B) flies. C, G–V relationships for the peak outward currents in the above genotypes. Error bars represent SEM. Wild type, n = 6; slob, n = 7.