Figure 3. Two distinct binding modes of triazole-containing influenza inhibitors 6-8.

Surface representations of the enzyme active site in N8:6 (a), N8:7 (b) and N8:8 (c) complexes, with ligand in stick format. The 150-cavity (indicated by an asterisk (*)) of N8:7 and N8:8 complexes remains open, in contrast to the complex with 6, where the 150-loop is closed.