Table 1.
Baseline clinical Features of 36 patients with AIDS-related diffuse large B-cell lymphoma
| Characteristics | Number (% or range) |
|---|---|
| Median age in years (range) | 35.5 (23-64) |
| Gender | |
| Male | 19 (52.8%) |
| Female | 17 (47.2%) |
| Race | |
| Black Africans | 22 (61.1%) |
| Mixed ancestry | 14 (38.9%) |
| Caucasians | 0 (0%) |
| Prior diagnosis of AIDS | |
| Yes | 21 (58.3%) |
| No | 15 (41.7%) |
| CD4 count at diagnosis | |
| MedianCD4 count (range) | 184 (28 – 2978) |
| Patients with CD4 count of < 100 cells/μl | 10/36 (27.8%) |
| ECOG Performance status | |
| 0-1 | 21 (58.3%) |
| ≥ 2 | 15 (41.7%) |
| Extranodal disease | |
| No | 8 (22.2%) |
| Yes | 28 (77.8%) |
| CNS involvement | |
| No | 30 (83.3%) |
| Yes | 6 (16.7%) |
| DLBCL Stage | |
| I | 1 (2.8%) |
| II | 4 (11.1%) |
| III | 3 (8.3%) |
| IV | 28 (77.8%) |
| International Prognostic Index (IPI)* | |
| 0 – 2 (Low / low-intermediate risk) | 17 (47.2%) |
| 3 – 5 (High-intermediate / high risk) | 19 (52.8%) |
| Age-adjusted IPI° (n = 35) | |
| 0 – 1 (Low / low-intermediate risk) | 7 (20.0%) |
| 2 – 3 (High-intermediate / high risk) | 28 (80.0%) |
| AIDS-related lymphoma risk score˜ | |
| 0 (Low risk) | 8 (22.2%) |
| 1 (Intermediate risk) | 16 (44.4%) |
| 2 (High risk) | 12 (33.3%) |
AIDS, Acquired Immunodeficiency syndrome; CD4, cluster of differentiation 4; ECOG, Eastern Cooperative Oncology Group; CNS, central nervous system
*
IPI, International Prognostic Index: a) Serum LDH above normal; b) Ann Arbor stage III or IV; c) ECOG performance status > 1; d) extranodal involvement > 1; e) Age > 60 years (1 point assigned for every adverse feature)26
°
Age-adjusted IPI: Includes all parameters as IPI with the exception of age (1 point assigned for every adverse feature)27
˜
AIDS-related lymphoma risk score: a) IPI score 3 – 5; b) Prior diagnosis of AIDS excluding DLBCL as sole criterion for AIDS (1 point assigned for each feature)19