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. 2013 Nov 1;19(13):1481–1493. doi: 10.1089/ars.2012.4537

FIG. 9.

FIG. 9.

Frataxin-deficient cells exhibit increased sensitivity to the TxnRD inhibitor auranofin. (A) Left panel: Frataxin-knockdown HeLa cells treated with 4 μM auranofin. Data indicate means of 6 replicates; ***p<0.001. Right panel: Frataxin-knockdown ND7/23 cells treated with 2.5 μM auranofin. Data indicate means of three replicates; **p<0.01. (B) Auranofin-treated YG8R DRG cells. Data indicate means of three replicates per dosage over five experiments, each experiment using one mouse per genotype. Error bars=SEM. **p<0.01 versus WT; #p<0.05 versus homo using a 1-tailed Student's t-test.