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The Trx fold. (A) Schematic representation of the Trx fold, the asterisk marks the position of the proximal active site cysteinyl residue, helices are shown in dark, sheets in light gray. Bacterial Grxs, such as (B) E. coli Grx1 (PDB accession number: 1EGR), are the most basic representations of the fold. (C) Human Trx1 (PDB: 3TRX) contains an additional N-terminal sheet and helix. (D, E) The 2-Cys Prx1 is shown as monomer (D) and (E) decameric torin.
