FIG. 5.

Mammalian Trxs, Grxs, and Prxs. Isoforms, subcellular localization, and confirmed interactions between the various redox proteins discussed in this review. The active site sequences and the classes of proteins, respectively, are indicated in white. C, cytosol; M, mitochondrium; N, nucleus; P, peroxisome; S, secreted. The secretory compartments, that is, endoplasmatic reticulum, Golgi apparatus, and lysosomes, were excluded for reasons of clarity; however, these compartments contain Trx family proteins; see Table 1.