Table 1.
Members of the Trx Family of Proteins with Putative or Confirmed Redox Activity Encoded in the Human Genome Are Enlisted
| |
Uniprot |
Gene |
Name |
aa |
Compartment |
Trx-domain(s) |
Active site |
|---|---|---|---|---|---|---|---|
| Thioredoxin related | |||||||
| 1 | DJC16 | DNAJC16 | DnaJ homlog subfamily C member 16 | 782 | Membrane | 119–247 | CFSC |
| 2 | NHLC2 | NHLRC2 | NHL repeat-containing protein 2 | 726 | 43–200 | CINC? | |
| 3 | NXN | NXN | Nucleoredoxin | 435 | Cytosol, nucleus | (–), 167–321 | SAPC, CPPC |
| 4 | NXNL1 | NXNL1 | Nucleoredoxin-like protein 1 | 212 | Nucleus, membrane | 1–164 | CPQC |
| 5 | NXNL2 | NXNL2 | Nucleoredoxin-like protein 2 | 156 | 9–147 | CAPS? | |
| 6 | QSOX1 | QSOX1 | Sulfhydryloxidase 1 | 747 | Golgi, membrane, secreted | 36–156 | CGHC |
| 7 | QSOX2 | QSOX2 | Sulfhydryloxidase 2 | 698 | Nucleus, membrane, secreted | 34–178 | CGHC |
| 8 | TMX1 | TMX1 | Thioredoxin-related transmembrane protein 1 | 280 | ER, membrane | 27–132 | CPAC |
| 9 | TMX2 | TMX2 | Thioredoxin-related transmembrane protein 2 | 296 | Membrane | 114–269 | SNDC? |
| 10 | TMX3 | TMX3 | Protein disulfide-isomerase TMX3 | 454 | ER, membrane | 25–128 | CGHC |
| 11 | TMX4 | TMX4 | Thioredoxin-related transmembrane protein 4 | 349 | Membrane | 30–137 | CPSC |
| 12 | THIO | TXN | Thioredoxin 1 | 105 | Cytosol, nucleus, secreted | 1–105 | CGPC |
| 13 | THIOM | TXN2 | Thioredoxin 2, mitochondrial | 166 | Mitochondria | 61–166 | CGPC |
| 14 | TXND2 | TXNDC2 | Thioredoxin domain-containing protein 2 (Sp-Trx1) | 553 | Cytosol | 429–553 | CGPC |
| 15 | TXND3 | TXNDC3 | Thioredoxin domain-containing protein 3 (Sp-Trx2) | 588 | Cytosol | 2–119 | CGPC |
| 16 | TXND5 | TXNDC5 | Thioredoxin domain-containing protein 5 | 432 | ER lumen | 36–169, 170–295, 304–429 | CGHC, CGHC, CGHC |
| 17 | Q3KNW3 | TXNDC6 | TXNDC6 protein | 174 | CGPC | ||
| 18 | B7ZME0 | TXNDC8 | TXNDC8 protein | 95 | CGPC | ||
| 19 | A9Z1W9 | TXNDC8 | Thioredoxin domain-containing 8 (Spermatozoa) (Sp-Trx3) | 108 | CGPC | ||
| 20 | TXND9 | TXNDC9 | Thioredoxin domain-containing protein 9 | 226 | 74–180 | TFRC? | |
| 21 | TXD11 | TXNDC11 | Thioredoxin domain-containing protein 11 | 985 | ER, membrane | 92–214, 649–749 | CELC, CGFC |
| 22 | TXD12 | TXNDC12 | Thioredoxin domain-containing protein 12 | 172 | ER lumen | 27–172 | CGAC |
| 23 | TXD15 | TXNDC15 | Thioredoxin domain-containing protein 15 | 360 | Membrane | 153–296 | CRFS? |
| 24 | TXD16 | TXNDC16 | Thioredoxin domain-containing protein 16 | 825 | Secreted | 392–495 | ? |
| 25 | TXD17 | TXNDC17 | Thioredoxin domain-containing protein 17 | 123 | Cytosol | 41–123 | CPDC |
| 26 | TXNL1 | TXNL1 | Thioredoxin-like protein 1 (Txl1) | 289 | Cytosol | 2–109 | CGPC |
| 27 | TXN4A | TXNL4A | Thioredoxin-like protein 4A | 142 | Nucleus | DPTC? | |
| 28 | TXN4B | TXNL4B | Thioredoxin-like protein 4B | 149 | Nucleus | DPVC? |
| Protein disulfide isomerases | |||||||
|---|---|---|---|---|---|---|---|
| 29 | ERP27 | ERP27 | Endoplasmic reticulum resident protein 27 | 273 | ER | 39–152 | ? |
| 30 | ERP44 | ERP44 | Endoplasmic reticulum resident protein 44 | 406 | ER | 30–138 | CRFS |
| 31 | PDIA1 | P4HB | Protein disulfide-isomerase | 508 | ER, membrane | 18–134, 349–475 | CGHC, CGHC |
| 32 | PDIA2 | PDIA2 | Protein disulfide-isomerase A2 | 525 | ER | 27–152, 367–496 | CGHC, CTHC |
| 33 | PDIA3 | PDIA3 | Protein disulfide-isomerase A3 | 505 | ER | 25–133, 343–485 | CGHC, CGHC |
| 34 | PDIA4 | PDIA4 | Protein disulfide-isomerase A4 | 645 | ER | 21–169, 158–301, 505–636 | CGHC, CGHC, CGHC |
| 35 | PDIA5 | PDIA5 | Protein disulfide-isomerase A5 | 519 | ER | 134–261, 270–384, 378–506 | CSMC, CGHC, CPHC |
| 36 | PDIA6 | PDIA6 | Protein disulfide-isomerase A6 | 440 | ER | 20–133, 154–287 | CGHC, CGHC |
| Glutaredoxin related | |||||||
|---|---|---|---|---|---|---|---|
| 37 | GLRX | GLRX | Glutaredoxin 1 | 106 | Cytosol, nucleus, secreted | 3–106 | CPYC |
| 38 | GLRX2 | GLRX2 | Glutaredoxin 2 | 164 | Mitochondria | 57–157 | CSYC |
| 39 | GLRX3 | GLRX3 | Glutaredoxin 3 | 335 | Cytosol, nucleus | 2–117, 144–236, 237–335 | APQC, CGFS, CGFS |
| 40 | GLRX5 | GLRX5 | Glutaredoxin 5 | 157 | Mitochondria | 42–145 | CGFS |
| 41 | GRCR1 | GRXCR1 | Glutaredoxin domain-containing Cys-rich protein 1 | 290 | 127–234 | CPSC (CSVC, CTAC) | |
| 42 | GRCR2 | GRXCR2 | Glutaredoxin domain-containing Cys-rich protein 2 | 248 | CFHC (CSLC, CPAC) | ||
| 43 | PGES2 | PTGES2 | Putative uncharacterized protein PTGES2 | 377 | Cytosol, golgi, membrane | 90–193 | CPFC |
| 44 | TRXR1 | TXNRD1_v3 | Thioredoxin reductase 1, cytoplasmic (TrxR1_v3) | 649 | Cytosol, nucleus | 56–156 | CTRC |
| 45 | TRXR3 | TXNRD3 | Thioredoxin reductase 3 (TGR) | 754 | Cytosol, nucleus, ER | 167–267 | CPHS |
| 46 | YD286 | Glutaredoxin-like protein YDR286C homolog | 115 | 1–115 | CPLC |
| Peroxiredoxins | |||||||
|---|---|---|---|---|---|---|---|
| 47 | PRDX1 | PRDX1 | Peroxiredoxin-1 | 199 | Cytosol, nucleus, Secreted | 6–165 | CPTE |
| 48 | PRDX2 | PRDX2 | Peroxiredoxin-2 | 198 | Cytosol, nucleus, secreted | 6–164 | CPTE |
| 49 | PRDX3 | PRDX3 | Peroxiredoxin-3 | 256 | Mitochondria | 63–221 | CPTE |
| 50 | PRDX4 | PRDX4 | Peroxiredoxin-4 | 271 | Cytosol, secreted, ER | 79–237 | CPTE |
| 51 | PRDX5 | PRDX5 | Peroxiredoxin-5 | 214 | Cytosol, mitochondria, peroxisomes | 56–214 | CSKT |
| 52 | PRDX6 | PRDX6 | Peroxiredoxin-6 | 224 | Cytosol, vesicles, lysosomes | 5–169 | CTTE |