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. 2013 Nov 1;19(13):1469–1480. doi: 10.1089/ars.2012.4845

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 6. — Production of ROS by mitochondrial Complex I in different situations where supercomplexes are maintained or disassembled. The percent value of ROS production measured in all the samples listed in Table 1 is plotted in the graph against the corresponding ratio of free Complex I versus total Complex I. The statistical analysis of the data using the Pearson's parametric test indicates a positive correlation (r=0.884, p<0.05) between ROS generation and relative amount of free Complex I in the R4B and in the SMP samples (black symbols). The BHM samples (gray symbols) were not included in the correlation analysis because the existence of endogenous antioxidant systems operating to reduce ROS levels in the mitochondria might have counteracted the dramatic effects of the complete dissociation of Complex I, thus leading to a two-fold only increase of the measured ROS production. SMP, submitochondrial particles.