Table 3.

Incidence of white matter disorder groups among children

Disorder	PHIS and PPM CNMC data set*
Multiple sclerosis	27 cases (4.08 cases/1 million children) **
Neuromyelitis optica	5 cases (0.76 cases/1 million children)
Transverse Myelitis	5 cases (0.76 cases/1 million children)
Optic Neuritis	19 cases (2.87 cases/1 million cases)
Acute disseminated encephalomyelitis	26 cases (3.93 cases/1 million children)
Leukodystrophy	50 cases (7.56 cases/1 million children)
Genetic leukoencephalopathy	28 cases (4.23 cases/1 million children)
Total progressive acquired white matter#	32 cases (4.83 cases/1 million children)
Total acquired white matter	87 cases (13.14 cases/1 million children)
Total Inherited white matter	78 cases (11.79 cases/1 million children)
Total acquired and inherited white matter disease	165 (24.9 cases/1 million)

Abbreviations: PHIS (Pediatric Health Information System), PPM (Physician Practice Management system), CNMC (Children’s National Medical Center)

All cases 0–19 years diagnosed with white matter disorders between January 1, 2004–December 31,2009

^*CDC Wonder Surveillance Census Projection Estimates for the years 2004–2009 for children ages 0–19: 6, 619, 841 children in the DC metro area (denominator used to calculate incidence estimates)

^**an additional 5 cases of progressive acquired white matter not otherwise specified (NOS) were identified that did not fulfill full criteria for MS but are still reflected in the total progressive acquired white matter disorder cases.

^#total progressive acquired demyelinating disorders included MS, and NMO