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. 2013 Nov;92(11):976–981. doi: 10.1177/0022034513504952

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Figure 4. — NDs induced osteoblast differentiation and proliferation. BMP-2 and bFGF delivered by ND induced osteoblast differentiation and proliferation, respectively. (A) Day 5 alkaline phosphatase activity normalized to DNA content from C2C12 cells incubated with various concentrations of ND-BMP or BMP-2 alone (doses listed indicate initial synthesis conditions). (B) Total protein released from ND clusters demonstrates pH dependence and a near-linear profile during the first 2 hrs (Appendix Fig. 4). (C) Day 5 alkaline phosphatase activity normalized to DNA content from C2C12 cells incubated with various amounts of FGF as ND-BF or ND-FGF. FGF inhibited alkaline phosphatase production in a dose-dependent fashion. (D) Day 5 total DNA content from C2C12 cells incubated with various doses of FGF as ND-BF or ND-FGF. FGF induced proliferation of C2C12 cells in a dose-dependent fashion.