Figure 3.

Subpopulations of wild-type and KIT-mutant GISTs. (a) Adult wild-type GISTs are segregated into four groups based on the expression levels of the IGF1R, neural marker, INSR, KIT, CD34 and IGF2 genes, and SDHB protein. Pediatric GISTs most closely resemble the adult wild-type GISTs with high relative expression of IGF1R, neural markers, INSR, KIT, and CD34, and low relative expression of IGF2. SDHB protein was detected in 16/19 IGF1R^high adult wild-type GISTs. (b) Some KIT-mutant GISTs exhibit similarities in relative CD34 and INSR expression compared with adult wild-type IGF1R^low GISTs. GIST, gastrointestinal stromal tumor; IGF1R, insulin-like growth factor 1 receptor.