Table 1.

Target gene expression relative to GAPDH in GIST subtypes

	Heatmap cluster (genotype)
Gene	1 (KIT)	2 (PDGFRA)	3 (KIT)	3 (WT)	4 (WT)	5 (WT)
IGF1R	0.54 ± 0.56	0.79 ± 0.59	0.26 ± 0.16	0.48 ± 0.48	20 ± 18	13 ± 16
IGF1	0.42 ± 0.51	8.2 ± 5.5	0.48 ± 0.67	0.41 ± 0.36	1.8 ± 1.7	3.1 ± 5.8
IGF2	235 ± 267	568 ± 613	334 ± 414	1680 ± 1187	402 ± 821	34 ± 85
INSR	0.49 ± 0.33	0.69 ± 0.98	0.15 ± 0.07	0.12 ± 0.12	0.28 ± 0.28	0.55 ± 0.60
IRS1	1.2 ± 2.3	12 ± 10	0.73 ± 1.0	1.1 ± 1.5	1.2 ± 2.4	1.8 ± 2.3
IRS2	7.0 ± 8.1	7.3 ± 13.2	6.4 ± 17.4	3.3 ± 3.2	17 ± 27	39 ± 72
CDH2	0.53 ± 0.74	0.050 ± 0.053	0.89 ± 2.1	0.82 ± 1.3	5.8 ± 4.3	11 ± 17
LHX2	0.073 ± 0.180	0.039 ± 0.060	0.085 ± 0.229	0.12 ± 0.18	5.2 ± 8.3	1.3 ± 3.7
NEFL	0.059 ± 0.167	0.023 ± 0.037	0.028 ± 0.078	1.6 ± 4.2	8.0 ± 13.7	2.8 ± 6.9
KIRREL3	0.031 ± 0.079	0.036 ± 0.037	0.007 ± 0.009	0.061 ± 0.122	1.9 ± 4.2	0.15 ± 0.36
KIT	53 ± 35	21 ± 13	62 ± 32	70 ± 36	83 ± 54	2.4 ± 3.4
PDGFRA	0.28 ± 0.35	26 ± 15	2.5 ± 3.2	3.4 ± 6.3	0.76 ± 1.5	1.5 ± 1.5
CD34	4.6 ± 4.2	24 ± 15	73 ± 39	84 ± 61	62 ± 69	10 ± 13
HIF1	3.5 ± 2.1	4.2 ± 1.2	2.4 ± 0.9	4.4 ± 2.3	9.5 ± 5.5	12.9 ± 6.9

Values are expressed as the percent ratio of the target gene relative to GAPDH. Numbers are the mean ± standard deviation. GIST, gastrointestinal stromal tumor; PDGFRA, platelet-derived growth factor receptor alpha; WT, wild type; IGF1R, insulin-like growth factor 1 receptor; HIF1, hypoxia-induced factor 1.