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. 2013 Feb 3;2(1):76–85. doi: 10.1002/cam4.50

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Copyright © 2012 The Authors. Published by Blackwell Publishing Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Computed tomography (CT) scans before and after treatment with vemurafenib (A–F) or ipilimumab (G and H) (patient 2). (A) CT scan (June 2010) before treatment: no cerebral metastases. (B) CT scan (August 2011) after treatment: new cerebral metastases. (C) CT scan (June 2010) before treatment: pulmonary metastases. (D) CT scan (August 2011) after treatment: complete remission. (E) CT scan (June 2010) before treatment: liver metastases. (F) CT scan (August 2011) after treatment: complete remission. (G) Magnetic resonance tomography (November 2011) after treatment with ipilimumab: progression of brain metastases with leptomeningeal metastases. (H) CT scan (November 2011) after treatment with ipilimumab: complete remission of liver metastases.