Fig. 4.

PIB-PET (from Mosconi et al. 2010b. Reprinted with permission from the National Academy of Sciences). Statistical parametric maps showing higher Pittsburgh Compound B (PIB) retention in cognitively normal subjects with a maternal family history of Alzheimer’s disease than in subjects with a paternal or no family history (upper two rows), and in cognitively normal subjects with a paternal family history of Alzheimer’s disease than in subjects with no family (lower two rows). Areas with higher PIB retention are represented on color-coded scales, reflecting Z scores. All results remained significant after controlling for age, gender, education, and APOE status