Figure 1.

Magnitudes of PE-induced contractions in the murine aorta in the presence of l-NAME. (A–D) Original recordings of PE-induced contraction in aortic rings from a CTR (A), sm-cGKI^−/− (B), Trpc3^−/− (C), and Trpc6^−/− (D) mouse. Bars indicate the presence of PE (3 µM) and l-NAME (100 µM), respectively. (E) Magnitudes of PE-induced contractions in aortic rings from the indicated mouse line in which NO synthases were inhibited by l-NAME. Columns represent mean ± SEM. Numbers represent the number of experiments. Data were analysed using ANOVA followed by the Bonferroni post hoc test, which indicated no statistically significant differences between Ctr and the respective mouse strain.