Table 4. Multiple regression of log transformed (ln) hepcidin.

Variable	Regression coefficient (95% CI)	Standard error	p value
A) Ferritin restricted
Ferritin	0.04 (0.023, 0.058)	0.0083	<0.0001
Ferritin2	−0.00015 (−0.00028, −0.000066)	0.000039	0.001
B) Complete model
Ferritin	0.036 (0.028, 0.044)	0.0037	<0.001
Ferritin2	−0.00011 (−0.00015, −0.000076)	0.000017	<0.001
Hepcidin:ferritin	1.88 (1.43, 2.34)	0.22	<0.001

A) Model using ferritin alone. 95% CI, 95% confidence intervals. Overall model parameters: sum of squares 17.2; 20 degrees of freedom; mean square 0.86; variance ratio (F) 11.0; adjusted r² = 60.0; overall p value for model = 0.0001. B) The final model for ln(hepcidin), generated by stepwise multiple regression in data from 21 HHT patients. Overall model parameters: sum of squares 17.2, 20 degrees of freedom, mean square 0.86, variance ratio (F) 81.5, adjusted r² = 92.4, overall p value for model <0.0001. No other captured variable contributed to the model.