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. 2013 Oct 16;8(10):e76474. doi: 10.1371/journal.pone.0076474

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© 2013 Qu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A), bisulfite genomic sequencing analysis of DCA-treated HepG2 cells. After the treatment of DCA, DNA was extracted and subjected to bisulfite modification. Bisulfite modified DNA was amplified by BSP as described under Materials and methods and then sequenced. Pointed star represents methylated CpG sites. (B), DNA methylation profiles of individual methylated CpG dinucleotides in DCA-treated HepG2 cells. After BSP, five clones were randomly selected and sequenced. The methylated sequences were checked for alignment using MethBLAST. The open and closed circles represent unmethylated or methylated cytosines, respectively.