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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Int J Biochem Cell Biol. 2013 Aug 2;45(11):2496–2500. doi: 10.1016/j.biocel.2013.07.018

Figure 1. Phenotype of arg−/− hippocampal CA1 neurons.

Figure 1

A, Representative reconstructions obtained from dye-filled live neurons. Dendrites develop normally in arg−/− mice through postnatal day 21 (P21). However, dendrites begin to regress around P31 and dendrite length (here) and complexity (not shown) are significantly reduced by P42. B, Representative confocal micrographs from apical dendrites labeled by thy1-GFP transgene expression. Scale bar 10 μm. Spines densities arg−/− neurons in are comparable to WT early in development, but by P31 are significantly reduced. C, Representative electron micrograph of a Schaffer-collateral synapse. Scale bar 500nm. Synapses density is normal at P21, but reduced by 30% in arg−/− mice at P31 and P42. Data represented in graphs obtained from (Gourley et al., 2012, Moresco et al., 2005, Sfakianos et al., 2007) and representative images modified from (Kerrisk et al., 2013, Warren et al., 2012).