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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Hum Genet. 2013 Jun 23;132(11):1235–1243. doi: 10.1007/s00439-013-1325-0

Fig 4. Histamine H1 receptor in complex with doxepin (antihistamine drug).

Fig 4

Nine variants from the ESP6500 (all with MAF < 1%) were mapped onto the PDB structure 3rze (Shimamura et al. 2011). Four variants that clustered proximal to the doxepin binding site are shown. Variant positions appear as green balls. Doxepin E-isomer is shown in dark blue. Doxepin Z-isomer is shown in light blue. Phosphate ion is shown in violet.