Table 2. Comparison of MuPIT interactive with similar available tools.

Only tools with functional websites as of February 2013 are included.

	MuPIT Interactive	LS-SNP/PDB	MutDB	SNPs3D	Mutation Assessor
Website URL	mupit.icm.jhu.edu/	http://ls-snp.icm.jhu.edu/ls-snp-pdb/	mutdb.org/	snps3d.org/	mutationassessor.org
Custom input?	Yes. Accepts user genomic coordinates	No. Limited to variants in dbSNP	No. Limited to variants in dbSNP and SwissProt	No. Limited to variants in dbSNP	Yes. Accepts user genomic or protein coordinates
3D-Display	Interactive and customizable via GUI*	Not interactive	Interactive	Interactive and customizable for power users by programming	Interactive
Simultaneous display of multiple variants on same structure	Yes	No	No	Yes	No
Position-Specific Annotation on protein structure	Yes	No	No	No	No
Batch Entry of Variants	Yes (high-throughput)	No	No	No	Yes (high-throughput)
Interface	Browser-based	Browser-based	Browser-based	Browser-based	Browser-based

^*Graphical User Interface