Table 2.
Genes repeatedly identified in GWAS
| Gene | Description | Class | # samples with clustered positive SNPs |
P value |
|---|---|---|---|---|
| BAI3 | brain-specific angiogenesis inhibitor | CAM | 7 | p<0.00001 |
| CDH13 | cadherin 13 | CAM | 16 | p<0.00001 |
| CLSTN2 | calsyntenin 2 | CAM | 14 | p<0.00001 |
| CNTNAP2 | contactin-associated protein-like 2 | CAM | 13 | p<0.00001 |
| CSMD1 | CUB and Suxhi multiple domains 1 | CAM | 18 | p<0.00001 |
| CTNNA2 | catenin α 2 | CAM | 12 | p<0.00001 |
| DAB1 | diabled homolog 1 | CAM | 13 | p<0.00001 |
| DSCAM | Down Syndrome cell adhesion molecule | CAM | 13 | p<0.00001 |
| NRXN1 | neurexin 1 | CAM | 12 | p<0.00001 |
| PTPTD | receptor protein tyrosine phophatase D | CAM | 13 | p<0.00001 |
| SGCZ | sarcoglycan zeta | CAM | 15 | p<0.00001 |
| ASTN2 | astrotactin 2 | CAM | 14 | p<0.00007 |
| CNTN4 | contactin 4 | CAM | 11 | p<0.00011 |
| CNTN6 | contactin 6 | CAM | 10 | p<0.00012 |
| LRP1B | low-density lipoprotein-related protein 1B | CAM | 14 | p<0.00015 |
| NRG1 | neuregulin 1 | CAM | 8 | p<0.00024 |
| ITGB8 | integrin β 8 | CAM | 6 | p<0.00026 |
| PTPRM | receptor protein tyrosine phophatase M | CAM | 12 | p<0.00029 |
| ROR1 | receptor tyrosine kinase-like orphan rec 1 | CAM | 9 | p<0.00029 |
| TRIO | triple functional domain/PTPRF interact | CAM | 7 | p<0.00069 |
| CSMD2 | CUB and Suxhi multiple domains 2 | CAM | 11 | p<0.00083 |
| CNTN5 | contactin 5 | CAM | 12 | p<0.00098 |
| CTNNA3 | catenin α 3 | CAM | 11 | p<0.00109 |
| LRRN6C | leucine rich repeat neuronal 6C | CAM | 14 | p<0.00134 |
| CTTND2 | catenin δ 2 | CAM | 8 | p<0.00327 |
| ANKS1B | ankyrin repeat sterile α domain 1B | CAM | 8 | p<0.00341 |
| SEMA3C | semaphorin 3C | CAM | 4 | p<0.00631 |
| RYR3 | ryanodine receptor 3 | CHA | 14 | p<0.00001 |
| CAMK1D | calcium/calmodulin-dependent protein kinase 1D |
ENZ | 11 | p<0.00001 |
| CHN2 | chimerin 2 | ENZ | 10 | p<0.00001 |
| FHIT | fragile histidine triad gene | ENZ | 16 | p<0.00001 |
| PRKG1 | cGMP-dependent protein kinase I | ENZ | 17 | p<0.00001 |
| SERPINA1 | serpin peptidase inhibitor A 1 | ENZ | 6 | p<0.00001 |
| LARGE | like-glycosyltransferase | ENZ | 11 | p<0.00002 |
| UST | uronyl-2-sulfotransferase | ENZ | 7 | p<0.00017 |
| DAPK1 | death-associated protein kinase 1 | ENZ | 8 | p<0.00024 |
| GALNTL4 | UDPNAc-α-D-galactosamine:plypeptide Nacgalactosaminyltransferase-like 4 |
ENZ | 9 | p<0.00040 |
| CAPN13 | calpain 13 | ENZ | 7 | p<0.00042 |
| PDE4D | cAMD-specific phophodiesterase 4D | ENZ | 10 | p<0.00055 |
| AKAP13 | protein kinase A anchor protein 13 | ENZ | 9 | p<0.00062 |
| ST6GALNAC3 | αNAcneuraminyl-2,3-β-galactosyl-1,3- Nacgalactosaminide α2,6-sialyltransgerase 3 |
ENZ | 11 | p<0.00080 |
| SERPINA2 | serpin peptidase inhibitor A 2 | ENZ | 4 | p<0.00138 |
| DGKB | diacylglycerol kinase β | ENZ | 9 | p<0.00138 |
| FGF14 | fibroblast growth factor 14 | LIGAND | 10 | p<0.00001 |
| GRM7 | metbotropic glutamate receptor 7 | REC | 11 | p<0.00001 |
| GPR39 | G protein-coupled receptor 39 | REC | 6 | p<0.00033 |
| ABCC4 | ATP-binding cassette C4 | TRANSP | 7 | p<0.00001 |
| SLC24A4 | solute carreir family 24 member 3 | TRANSP | 10 | p<0.00033 |
| XKR4 | XK family member 4 | TRANSP | 9 | p<0.00091 |
| SLC9A9 | solute carrier family 9 member 9 | TRANSP | 10 | p<0.00134 |
Summary of genes repeatedly identified in GWAS for drug dependence and related phenotypes, after Uhl et al., (2008). P values represent Monte Carlo analyses of the likelihood of repeatedly seeing each gene in multiple GWAS.