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. 2013 Oct 17;3:2973. doi: 10.1038/srep02973

Figure 5. Impaired UVB-induced ear skin swelling upon blockade of the PGE2-EP4 pathway.

Figure 5

(A) Ptges+/+ and Ptges−/− mice were treated with 6-AN and exposed to UVB. Their ear swelling responses were examined. Data are presented as means ± SEM. *, P < 0.05. (B) Blood flow in the ears of Ptges+/+ and Ptges−/− mice at day 5 after UVB irradiation. Data are presented as means ± SEM. *, P < 0.05. (C) The histological findings in Ptges+/+ and Ptges−/− mice were scored. Data are presented as means ± SEM. *, P < 0.05. (D) Expression of EP1, EP2, EP3 and EP4 mRNAs after UVB exposure. Data are presented as means ± SEM. *, P < 0.05. (E) EP4 receptor signaling blockade impairs 6-AN-induced photosensitivity. Data are presented as means ± SEM. *, P < 0.05.