Table I. Baseline Characteristics vs. Day 4 of Energy Deprivation.

Characteristics and chemerin levels at 8 AM on Day 1 and Day 4 of fed state, 72-hour fasting with placebo administration, and 72-hour fasting with metreleptin administration. Data were analyzed by ANOVA for repeated variables.

	Fed State		Fasting + Placebo		Fasting + Leptin
	Day 1	Day 4	Day 1	Day 4	Day 1	Day 4	p trt	p time	p trt*time
Body weight (kg)	57.1 ± 6.5	57.9 ± 6.4	56.9 ± 7.5	55.4 ± 6.9	56.5 ± 6.4	54.4 ± 5.8*	0.002 (0.001)	0.033 (0.033)	0.033 (0.048)
BMI (kg/m^2)	21.8 ± 2.1	22.2 ± 2.1	21.9 ± 2.7	21.4 ± 2.6	21.7 ± 2.7	20.9 ± 2.6*	0.001 (0.013)	0.021 (0.021)	0.019 (0.031)
Insulin (µIU/ml)	5.7 ± 1.8	8.1 ± 2.8	6.1 ± 2.0	1.2 ± 0.6*	6.9 ± 3.3	1.2 ± 0.9*	<0.001 (<0.001)	<0.001 (<0.001)	<0.001 (<0.001)
Leptin (ng/ml)	11.2 ± 4.5	16.7 ± 3.3	14.7 ± 6.3	2.8 ± 0.8*	12.5 ± 4.6	29.6 ± 5.4*	<0.001 (<0.001)	0.282 (0.282)	<0.001 (<0.001)
sTNFRII (pg/ml)	1753.75 ± 170	1706.5 ± 257	1775.9 ± 339	1810.8 ± 230	1596.6 ± 178	1865.9 ± 158	0.726 (0.726)	0.644 (0.644)	0.651 (0.651)
Chemerin (ng/ml)	164.6 ± 37.2	155.0 ± 42.4	161.1 ± 34.0	56.9 ± 26.6*	151.0 ± 34.5	50.9 ± 8.6*	<0.001 (0.003)	<0.001 (<0.001)	0.006 (0.027)

Values are means +/− SD. Means with * indicate significant difference between day 1 and day 4 within a state. P trt demonstrates significance of intervention (fed, fasting, leptin); p time demonstrates significance of time between days; p trt*time demonstrates significance of intervention and time interaction.