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. 2013 Oct 17;4:129. doi: 10.3389/fphar.2013.00129

Table 2.

The effect of Erythropoietin, Anakinra and TBI (vehicle/sham) on genes of interest (1.5 fold change, p < 0.05).

Affymetrix ID Gene symbol Genes EPO vehicle Anakinra vehicle Vehicle sham
24 H
10775968 Alb Albumin 1.91 n.s. 0.50
10911380 Aldh1a2 Aldehyde dehydrogenase 1 family, member A2 1.97 n.s. n.s.
10744425 Alox15 Arachidonate 15-lipoxygenase 3.76 1.95 n.s.
10821016 Ccnb1 Cyclin B1 1.50 n.s. n.s.
10717195 Ccnb2 Cyclin B2 1.53 n.s. n.s.
10921163 Ccr1 Chemokine (C-C motif) receptor 1 0.49 0.59 9.78
10829761 Cdk1 Cyclin-dependent kinase 1 1.50 n.s. 2.36
10775896 Cxcl3 Chemokine (C-X-C motif) ligand 2 0.48 n.s. 11.92
10924245 Cxcr2 Chemokines (C-X-C motif) receptor 2 0.49 0.47 18.82
10825153 Fcgr1a Fc fragment of IgG, high affinity Ia, receptor 0.66 n.s. 7.36
10755148 Fetub Fetuin B n.s. 0.64 2.48
10926967 Gsta2 Glutathione-S-transferase alpha 2 1.56 n.s. 0.42
10849841 IL1b Interleukin 1 beta 0.48 0.59 6.82
10922816 IL1r2 Interleukin 1 receptor, type II 0.53 0.64 7.10
10834109 IL1rn Interleukin 1 receptor antagonist 0.46 0.59 17.23
10922882 IL18rap Interleukin 18 receptor accessory protein 0.64 0.66 2.38
10907689 Itga5 Integrin, alpha 5 0.66 n.s. 4.63
10711299 Itgax Integrin, alpha X 0.61 0.44 4.35
10810736 Lcat Lecithin cholesterol acyltransferase 1.55 n.s. 0.44
10736312 Nos2 Nitric oxide synthase 2, inducible 0.42 0.51 7.71
10873341 Pla2g2a Phospholipase A2, group IIA n.s. 1.77 2.23
10708214 Prc1 Protein regulator of cytokinesis 1 1.52 1.64 1.54
10835817 Ptgs1 Prostaglandin-endoperoxide synthase 1 n.s. 1.52 n.s.
10764551 Ptgs2 Prostaglandin-endoperoxide synthase 2 0.56 n.s. 2.67
10742194 Pttg1 Pituitary tumor-transforming 1 1.57 n.s. n.s.
10738130 Rara Retinoic acid receptor, alpha 0.66 n.s. 1.83
10786108 Rarb Retinoic acid receptor, beta 1.94 n.s. 0.25
10827686 RT1-M6-1 RT1 class I, locus M6, gene 1 0.46 n.s. 2.13
10827691 RT1-M6-2 RT1 class I, locus M6, gene 2 0.48 n.s. 2.21
10817071 S100a8 S100 calcium binding protein A8 n.s. 0.66 3.28
10934608 Tir13 Toll-like receptor 13 0.64 0.17 6.31
10770577 Tgfb2 Transforming growth factor, beta 2 0.63 n.s. n.s.
10746976 Top2a Topoisomerase (DNA) II alpha 1.50 n.s. 3.26
72 H
10885393 Akap5 A kinase (PRKA) anchor protein 5 1.54 n.s. 0.57
10932912 Alas2 Aminolevulinate, delta-, synthase 2 2.96 1.87 n.s.
10744425 Alox15 Arachidonate 15-lipoxygenase 14.84 1.75 n.s.
10736697 Ccl2 Chemokines (C-C motif) ligand 2 0.66 n.s. 45.91
10736702 Ccl7 Chemokines (C-C motif) ligand 7 0.52 n.s. 9.29
10858566 Clec4a2 C-type lectin domain family 4, member A2 0.61 n.s. 7.66
10866019 Clec7a C-type lectin domain family 7, member A 0.59 n.s. 30.82
10914614 Ccr2 Chemokine (C-C motif) receptor 2 0.51 n.s. 11.00
10865585 Cd4 Cd4 molecule 0.53 n.s. 2.86
10856274 Cd8a CD8a molecule 0.57 n.s. 5.90
10856265 Cd8b CD8b molecule 0.56 n.s. 5.85
10802013 Cd72 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.64 n.s. 3.93
10897428 Csf2rb Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.60 n.s. 10.88
10767373 Cxcr4 Chemokine (C-X-C motif) receptor 4 0.63 n.s. 2.65
10811571 Cyba Cytochrome b-245, alpha polypeptide 0.66 n.s. 3.95
10936899 Cybb Cytochrome b-245, beta polypeptide 0.65 n.s. 17.68
10732652 Dusp1 Dual specificity phosphatase 1 n.s. 1.51 0.40
10828344 HLA-DRAa Major histocompatibility complex, class II, DR alpha 0.55 0.65 7.18
10831657 HLA-DRB1a Major histocompatibility complex, class II, DR beta 1 0.63 0.69 2.50
10828351 HLA-DQA1a Major histocompatibility complex, class II, DQ alpha 1 0.60 0.71 3.92
10767518 Ikbke Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.66 n.s. 2.30
10834109 ILr1n Interleukin 1 receptor antagonist 0.55 n.s. 9.09
10938654 IL2rg Interleukin 2 receptor, gamma 0.65 n.s. 4.34
10832306 Itgb2 Integrin, beta 2 0.65 n.s. 7.52
10907689 Itgb5 Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.60 n.s. 4.13
10907881 Mmp3 Matrix metallopeptidase 3 0.43 0.51 3.22
10780205 Mmp14 Matrix metallopeptidase 14 (membrane-inserted) 0.61 n.s. 2.66
10796476 Mrc1 Mannose receptor, C type 1 0.63 n.s. 4.64
10757898 Ncf1 Neutrophil cytosolic factor 1 0.60 n.s. 6.81
10764722 Ncf2 Neutrophil cytosolic factor 2 0.65 n.s. 4.32
10873336 Pla2g2a Phospholipase A2, group IID 0.54 n.s. 4.76
10828351 RT1-Ba RT1 class II, locus Ba 0.60 n.s. 3.92
10831557 RT1-Db1 RT1 class II, locus Db1 0.63 n.s. 2.50
10797509 Syk Spleen tyrosine kinase 0.66 n.s. 4.14
7 DAYS
10819379 Adh1ca Alcohol dehydrogenase (class 1) 1.64 n.s 1.61
10854406 Akr1b10a Aldo-ketoreductase family 1, member B10 1.90 n.s. n.s.
10911380 Aldh1a2 Aldehyde dehydrogenase 1 family, member A2 1.81 n.s. 1.61
10722992 Anpep Alanyl (membrane) aminopeptidase 2.44 n.s. 2.74
10744425 Alox15 Arachidonate 15-lipoxygenase 18.75 n.s. n.s.
10719524 Apolipoprotein C-I (Apoc1) 1.69 n.s. n.s.
10848030 Bbox1 Butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 n.s. 1.61 n.s.
10914614 Ccr2 Chemokine (C-C motif) receptor 2 n.s. 0.63 n.s.
10803991 Cd14 CD14 molecule 1.59 n.s. 2.06
10940473 Cd36 CD36 molecule (thrombospondin receptor) 3.97 n.s. 2.62
10935177 Cldn2 Claudin 2 3.27 3.85 0.19
10767373 Cxcr4 Chemokine (C-X-C motif) receptor 4 1.51 n.s. n.s.
10936899 Cybb Cytochrome b-245, beta polypeptide 1.65 n.s. 10.08
10765212 F5 Coagulation factor V (proaccelerin, labile factor) 2.22 3.03 0.46
10794734 F13a1 Coagulation factor XIII, A1 polypeptide 2.00 n.s. n.s.
10810778 Dpep2 Dipeptidase 2 1.67 n.s. 1.84
10928761 Fn1 Fibronectin 1 2.37 n.s. 2.23
10939901 Gpr101 G protein-coupled receptor 101 (Gpr101) n.s. 1.83 0.54
10804221 Gpr151 G protein-coupled receptor 151 n.s. 1.82 n.s.
10825915 Gstm2 Glutathione S-transferase mu 2 1.78 n.s. n.s.
10806122 Hmox1 Hemeoxygenase (decycling) 1 1.98 n.s. 5.90
10937302 Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 1.90 0.46
10841693 Lbp Lipopolysaccharide binding protein 2.19 n.s. 1.94
10791250 Lpl Lipoprotein lipase 1.55 1.71 0.56
10874918 Ly96 Lymphocyte antigen 96 1.51 n.s. 2.63
10859392 Mgst1 Microsomal glutathione S-transferase 1 1.67 n.s. 1.72
10842239 Mmp9 Matrix metallopeptidase 9 1.85 n.s. n.s.
10907869 Mmp12 Matrix metallopeptidase 12 1.91 n.s. 5.62
10780205 Mmp14 Matrix metallopeptidase 14 (membrane-inserted) 1.60 n.s. 1.79
10893231 Mmp19 Matrix metallopeptidase 19 1.51 n.s. 2.91
10788427 Msr1a Macrophage scavenger receptor 1 2.53 n.s. 3.36
10821698 Osmr Oncostatin M receptor 1.51 n.s. 3.69
10860867 Pon1 Paraoxonase 1 3.55 3.53 n.s.
10860878 Pon3 Paraoxonase 3 1.79 n.s. n.s.
10873341 Pla2g2a Phospholipase A2, group IIA 1.61 n.s. n.s.
10873336 Pla2g2d Phospholipase A2, group IID 2.17 n.s. n.s.
10751295 Pla1a Phospholipase A1 member A 1.70 n.s. 1.68
10782271 Plau Plasminogen activator, urokinase 1.70 n.s. 4.36
10823819 Rxfp1 Relaxin/insulin-like family peptide receptor 1 n.s. 0.62 n.s.
10912439 Rbp1 Retinol binding protein 1, cellular 1.81 n.s. 1.54
10761047 Serpine1 Serpin peptidase inhibitor, clade E, member 1 2.71 n.s. n.s.
10819139 Tacr3 Tachykinin receptor 3 0.56 0.62 n.s.
a

A rat gene symbol was not provided by the Affymetrix annotation file for this transcript, however, IPA identified a human ortholog. Therefore, the gene symbol for the human ortholog is listed here.