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LOX–COX-derived eicosanoids in tumorigenesis. a Schematic representation of the generation of cyclic hemiketal (HK) eicosanoids from a converging 5-LOX/COX-2 pathway. Only the generation of HKD2 is illustrated. b Biosynthesis of hemiketals by a tight interaction between neutrophils– macrophages or neutrophils– tumor cells in an inflamed tumor could play a pro-tumorigenic role by stimulating angiogenesis
