Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
p53 levels are regulated by many factors such as circadian timing, cellular stress, and MDM2. Both physiological and stress induced p53 binds to the p53 response element of Per2 promoter which overlaps with the BMAL1 / CLOCK binding site (E-box) and suppresses BMAL1 / CLOCK mediated transcription of Per2 thereby modulating the circadian clock.
