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Circadian rhythms in three groups after treatment (T14). The circadian rhythm of mean arterial pressure in the vehicle-treated group exhibits an inverse rhythm (panel a) which is essentially normalized in the mRen2.Lewis rats medicated with either valsartan or the combination of valsartan/aliskiren (panel b). The circadian rhythms of heart rate (panel c) and locomotive activity (panel d) are not different from vehicle-treated rats.
